It depends on what you intend to do. Just LoRa modulation or support LoRaWAN protocol.
http://www.multitech.net/developer/software/mlinux/mlinux-software-development/
http://www.multitech.net/developer/software/mlinux/mlinux-software-development/mlinux-c-toolchain/
Python is ok for an application depending on what you need it to do. Just forwarding to cloud is probably a light lift. The development may be easier.
C is the best choice for performance.
Looking at the feeds http://www.multitech.net/mlinux/feeds/
mLinux 3 – python 2.7.3
mLinux 4 – python 2.7.12